Abstract

                                Type 2 diabetes mellitus is characterized by insulin resistance andhyperglycemia and accounts for 90 per cent of diabetes cases. Salaciareticulata Wight, a climbing shrub indigenous to India and Sri Lanka, is animportant source of anti-diabetic compounds. In this study, the abundanceof naringenin was estimated in various tissues of the plant using RP-HPLC.The highest concentration of naringenin was found in fresh and dried roots at3.4 and 3.2 %, respectively. Through in silico analysis affinity of naringenin toPPAR-γ, 11β-Hydroxysteroid-Dehydrogenase I, PPAR-α, PPAR-δ and GlycogenSynthase Kinase - 3β, the targets for type 2 diabetes mellitus drug targetswere -8.7, -8.4, -7.1, -8.4 and -7.8 kcal/mol, respectively.

Key words : Naringenin; RP-HPLC; Type 2 diabetes mellitus; Salacia reticulata Wight