Abstract

                                Piper betleis a Piperaceae family scented perennial creeper. The leaves are high in phenol, a compound with anti-tumor, anti-mutagenic, and immunomodulatory activities. This study aims to evaluate the bioactive compound in Piper betle leaves extract using Gas Chromatography Mass Spectrometry (GC-MS). Over 100 compounds were found in the GC-MS results, with 19 of them having a probability of greater than 30. The compound phentermine shows the highest peak at a retention time of 9.346 minutes, followed by Hexadecanoic acid, Tetradecanoic acid, Eugenol, Dodecanoic acid. Hexadecanoic acid shows the highest area% about 26.665%, indicating the highest composition of hexadecanoic acid in the betel leaf extract. The result revealed that the compound in betel leaf extract possesses medicinal properties.

Key words : Piper betle leaves; Gas Chromatography-Mass Spectroscopy; Retention Time; Area