Estimation of Naringenin in Salacia reticulata Wight, Fishing Targets and Harmonizing the Ligand for Type 2 Diabetes
Author:Anurabh Chakravarty, Gnanam R, Suresh J, Santhanakrishnan V P
p-ISSN:0024-9602, e-ISSN:2582-5321, Vol:107, Issue:september(7-9)
Type 2 diabetes mellitus is characterized by insulin resistance andhyperglycemia and accounts for 90 per cent of diabetes cases. Salaciareticulata Wight, a climbing shrub indigenous to India and Sri Lanka, is animportant source of anti-diabetic compounds. In this study, the abundanceof naringenin was estimated in various tissues of the plant using RP-HPLC.The highest concentration of naringenin was found in fresh and dried roots at3.4 and 3.2 %, respectively. Through in silico analysis affinity of naringenin toPPAR-γ, 11β-Hydroxysteroid-Dehydrogenase I, PPAR-α, PPAR-δ and GlycogenSynthase Kinase - 3β, the targets for type 2 diabetes mellitus drug targetswere -8.7, -8.4, -7.1, -8.4 and -7.8 kcal/mol, respectively.
Key words : Naringenin; RP-HPLC; Type 2 diabetes mellitus; Salacia reticulata Wight