From results, it could be concluded that early sowing of cotton on 1st August with higher GDDs decreased the weed interaction. This was accompanied by integrated weed management of pre-emergence application of pendimethalin 38.7% CS 0.68 kg/ha, followed by post-emergence pyrithiobac sodium 5% EC 62.5 g/ha, which resulted in higher weed control efficiency, seed cotton yield, net return, and B:C ratio.